Toremifene Memorial Sloan Kettering Cancer Center
If you need medical treatment for any reason other than cancer, always tell the healthcare professional that you are having cancer treatment. Give them the contact details for your cancer doctor or cancer team so they can ask for advice. Your doctor, nurse or pharmacist can explain the risk of these side effects to you. Toremifene (Fareston®) is a hormonal therapy drug used to treat breast cancer. It is best to read this information with our general information abouthormonal therapies and breast cancer. If you have questions about side effects, call your doctor.
Why is this medication prescribed?
- Your doctor, nurse or dietitian can give you more advice.
- If side effects cannot be managed, your doctor may suggest a different type of hormonal therapy.
- This medication may be covered under your prescription drug plan.
- Women should use 2 forms of birth control while using this medication.
In rats, toremifene causes regression of established dimethylbenzanthracene (DMBA)- induced mammary tumors. Based on its mechanism of action in humans and findings of increased pregnancy loss and fetal malformation in animal studies, FARESTON can cause fetal harm when administered to a pregnant woman. Toremifene caused embryo-fetal toxicities at maternal doses that were lower than the 60 mg daily recommended human dose on a mg/m2 basis.
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Increased toremifene elimination half-life in geriatric female patients; however, no change in clearance. Increased toremifene elimination half-life in patients with hepatic impairment (i.e., cirrhosis, fibrosis). Increased toremifene volume of distribution in geriatric female patients; however, no change in AUC. Leukopenia and thrombocytopenia reported rarely; monitor leukocyte and platelet counts in patients with leukopenia and thrombocytopenia.
Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant while on this medication. Effective birth control is necessary during treatment even if your menstrual cycle stops. You should consult with your healthcare team before breastfeeding while receiving this medication. Nonsteroidal, triphenylethylene derivative with potent antiestrogenic properties (also has estrogenic effects). Competitively binds to estrogen receptors on tumors and inhibits the growth stimulating effects of estrogen. Toremifene has been shown to prolong the QTc interval in a dose- and concentration-related manner.
Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. This medicine is available only with your doctor’s prescription. Hot flashes, sweating, nausea, vomiting, dry eyes, or dizziness may occur.
Distributed into milk in rats; not known whether distributed into human milk. Available as https://aereolink.com.br/how-steroids-can-help-speed-recovery-from-injuries-5/ citrate; dosage expressed in terms of toremifene. Under investigation as a preventive agent for prostate cancer† [off-label] in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer. Antineoplastic agent; a nonsteroidal estrogen agonist-antagonist that is structurally and pharmacologically related to tamoxifen. FARESTON is contraindicated in patients with known hypersensitivity to the drug.